Publications

1998 _top

He Q, Tran Minh NN, Edelman K, Viljanen MK, Arvilommi H, Mertsola J.
Cytokine mRNA expression and proliferative responses induced by pertussis toxin, filamentous hemagglutinin and pertactin of Bordetella pertussis in the peripheral blood mononuclear cells of infected and immunized schoolchildren and adults.

Infect Immun 66:3796-3801, 1998.

He Q, Viljanen MK, Arvilommi H, Aittanen B, Mertsola J.
Whooping cough caused by Bordetella pertussis and Bordetella parapertussis in an immunized population.

JAMA 280:635-637, 1998.

Tran Minh NN, Edelman K, He Q, Viljanen MK, Arvilommi H, Mertsola J.
Antibody and cell-mediated immune responses to booster immunization with a new acellular pertussis vaccine in school children.

Vaccine 16:1604-1610, 1998.

GUEIRARD P., A. DRUILHE, M. PRETOLANI & N. GUISO.
Bordetella pertussis infection induces apoptotic death of bronchopulmonary cells in vitro.

Inf. Immun. (1998) 66: 1718-25.

BARON, S., E. NJAMKEPO, E. GRIMPREL, P. BEGUE, J.-C. DESENCLOS, J. DRUCKER & N. GUISO.
Epidemiology of Pertussis in France in 1993-1994: Bordetella pertussis is still circulating in a country with a high level of coverage by an effective whole-cell pertussis vaccine.

Ped. Inf. Dis. J. (1998) 17: 412-418.

WOOD G.E., N. KHELEF, N. GUISO & R.L. FRIEDMAN.
Identification of Btr-regulated genes using a titration assay. Search for a role for this transcriptional regulator in the growth and virulence of Bordetella pertussis.

Gene (1998) 209: 51-58.

I. ITEMAN, M.-P. PREZIOSI, A. YAM & N. GUISO.
Evaluation of serology based on IgG ELISA for pertussis toxin and filamentous hemagglutinin in the diagnosis of pertussis cases. A case study from Senegal.

Clin. Diag. Lab. Immunol. (1998) 5: 130-134.

PRADEL E., N. GUISO & C. LOCHT.
Identification of AlcR, and AraC-Type Regulator of Alcaligin Siderophore Synthesis in Bordetella bronchiseptica and Bordetella pertussis.

J. Bacteriol. (1998) 180: 871-880.

GUEIRARD P., K. LEBLAY, A. LE COUSTUMIER, R. CHABY & N. GUISO.
Variation in Bordetella bronchiseptica lipopolysaccharides structure during human infection.

FEMS Microbiol. Lett. (1998) 162: 331-337.

Willems R.J.L, J. Kamerbeek, C.A.W. Geuijen, J. Top, H. Gielen, W. Gaastra and F.R. Mooi (1998)
The efficacy of a whole cell pertussis vaccine and fimbriae against B. pertussis and B. parapertussis infections in a respiratory mouse model.

Vaccine, 16, 1998, 410-416.

Mooi, F.R., H. van Oirschot, K. Heuvelman, H.G.J. van-der-Heide, W. Gaastra and R.J.L. Willems (1998)
Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in the Netherlands: temporal trends and evidence for vaccine-driven evolution.

Infect. Immun. 66, 670-675.

Cecile AW Geuijen, RJL Willems, P. Hoogerhout, WC Puijk, RH Meloen and FR Mooi (1998)
Identification and characterization of heparin-binding regions of the Fim2 subunit of Bordetella pertussis.

Infect. Immun. 66, 1822-1826.

Simondon, F., Iteman, I., Preziosi, M.P., Yam, A. and Guiso, N.
Evaluation of serology based on IgG ELISA for pertussis toxin and filamentous hemagglutinin in a diagnosis of pertussis cases. A case study from Senegal.

Clin. Diag. Lab. Immunol. (1998) 5: 130-134.

1999 _top

Tran Minh NN, He Q, Edelman K, Viljanen MK, Arvilommi H, Mertsola J.
Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children.

Pediatr Infect Dis J 18:366-370, 1999.

He Q, Arvilommi H, Viljanen MK, Mertsola J.
Outcome of Bordetella infections in vaccinated children: effect of bacterial number in nasopharynx and age of patients.

Clin Diagn Lab Immun 6:534-536, 1999.

Edelman K, Malmstr�m K, He Q, Savolainen J, Terho E, Mertsola J.
Local reactions and IgE antibodies to pertussis toxin after acellular DTP immunization.

Eur J Pediatr 158:989-994,1999.

Tran Minh NN, He Q, Ramalho A, Viljanen MK, Arvilommi H, Mertsola J.
Acellular vaccines containing reduced quantities of pertussis antigens given as a booster in adolescents.

Pediatrics 104:E701-706, 1999.

GUISO N., C. CAPIAU, G. CARLETTI, J. POOLMAN & P. HAUSER.
Intranasal murine model of Bordetella pertussis infection. I. Prediction of protection in human infants by acellular vaccines.

Vaccine (1999) 17: 2366-2376.

BOURSAUX-EUDE C., S. THIBERGE, G. CARLETTI & N. GUISO.
Intranasal murine model of Bordetella pertussis infection. II. Sequence variation and protection induced by a tricomponent acellular vaccine

Vaccine (1999) 17: 2651-2660.

HOZBOR D., M.E. RODRIGUEZ, J. FERNANDEZ, A. LAGARES, N. GUISO & O. YANTORNO.
Release of outer membrane vesicules from Bordetella pertussis.

Curr. Microbiol. (1999) 17: 273-278.

HOZBOR D., F. FOUQUE & N. GUISO.
Detection of Bordetella bronchiseptica by polymerase chain reaction.

Res. Microbiol. (1999) 150: 333-341.

NOUVELLON M., J.-F. GEHANNO, M. PESTEL-CARON, C. WEBER, J.-F. LEMELAND & N. GUISO.
Usefulness of pulsed-field gel-electrophoresis in assessing nosocomial pertussis t.ransmission.

Infection Control and Hospital Epidemiology (1999) 20:758-760

GRIMPREL, E., S. BARON, D. LEVY-BRUHL, J.M. GARNIER, E. NJAMKEPO, N. GUISO & P. BEGUE.
Influence of vaccination coverage on pertussis transmission - The French experience.

Lancet (1999) 354(9191):1699-1700.

B.M. van-den-Berg, H. Beekhuizen, F.R. Mooi, R. van-Furth.
Role of Antibodies against Bordetella pertussis Virulence Factors in Adherence of Bordetella pertussis and Bordetella parapertussis to. Human Bronchial Epithelial cells.

Infect. Immun. 1999 67 (3): p. 1050-1055.

B.M. van-den-Berg, H. Beekhuizen, R.J.L. Willems, F.R. Mooi, and R. van-Furth.
Role of Bordetella pertussis Virulence Factors in Adherence to Epithelial Cell Lines Derived from the Human Respiratory Tract.

Infect. Immun. 1999 67 (3): p. 1056-1062.

Van-Loo, I.H.M, H.G.J. van-der-Heide, N.J.D. Nagelkerke, J. Verhoef, and F.R. Mooi.
Temporal trends in the population structure of Bordetella pertussis in the years 1949-1996 in a highly vaccinated population.

J Infect Dis, 1999; 179: 915-923.

Mooi F.R., Qiushui He, H. van-Oirschot, and J. Mertsola.
Variation in the Bordetella pertussis virulence factors pertussis toxin and pertactin in vaccine strains and clinical isolates in Finland.

Infect. Immun. 1999, 67; 3133-3134.

P. Mastrantonio, P. Spigaglia, H. van Oirschot, H. G. J. van der Heide, K. Heuvelman, P. Stefanelli and F. R. Mooi.
Antigenic variants in Bordetella pertussis strains isolated from vaccinated and unvaccinated children.

Microbiology 1999 145: 2069-2075.

Hellwig, S.M.M., W.L.W. Hazenbos, J.G.J. van-de-Winkel and F.R. Mooi (1999)
Evidence for an intracellular niche for B.pertussis in broncho-alveolar lavage cells of mice.

FEMS Microbiology Letters 26, 203-207.

2000 _top

Tran Minh NN, He Q, Edelman K, Putto-Laurila A, Arvilommi H, Viljanen MK, Mertsola J.
Immune responses to booster immunization with acellular pertussis vaccines in adults.

Vaccine 18:1971-1974, 2000.

PRADEL E., N. GUISO, F.D. MENOZZI & C. LOCHT.
Bordetella pertussis Ton B, a Bvg-independent virulence determinant.

Infect. Immun. (2000) 68, n�4:1919-1927.

L. BASSINET, GUEIRARD P., B. MAITRE, B. HOUSSET, P. GOUNON & N. GUISO.
Invasion of human tracheal epithelial cells by Bordetella pertussis. The role of adhesins and toxins in this process.

Infect. Immun. (2000) 68, n�4:1934-1941.

NJAMKEPO E., F. PINOT, D. FRANCOIS, N. GUISO, B.S. POLLA & M. BACHELET.
Adaptive responses of human monocytes infected by Bordetella pertussis: The role of adenylate cyclase hemolysin.

J. Cell. Physiol. (2000) 183:91-99.

NJAMKEPO E., F. DELISLE, I. HAGEGE, G. GERBAUD & N. GUISO.
Bordetella holmesii infection of a patient with sickle cell anemia: analysis of the isolate and comparison with other Bordetella holmesii reference.

Clin. Microb. Infect. (2000) 6:131-136.

MOOI FR, H. HALLANDER, F. WIRSING VON K�NIG, B. HO�T, & N. GUISO,
Epidemiological typing of Bordetella pertussis isolates : recommendations for a standard methodology.

Eur. J. Clin. Microbiol. and Infect. Dis. (2000) 19 :174-181.

BOURSAUX-EUDE C. & N. GUISO.
Polymorphism of the repeated regions of pertactin in Bordetela pertussis, Bordetella parapertussis and Bordetella bronchiseptica..

Infect. Immun. (2000), 68, n�8:4815-4817.

Mooi, F.R., H. Hallander, C.H. W. von-K�nig, B. Hoet, and N. Guiso. 2000
Epidemiological typing of Bordetella pertussis isolates: recommendations for a standard methodology.

Eur J Clin Microbiol Infect Dis. 2000; 19: 174-181.

van-den-Berg-BM; Beekhuizen-H; Van-Furth-R; Mooi-FR. 2000.
Binding of murine antibodies against whole-cell pertussis vaccine or filamentous haemagglutinin by Bordetella pertussis from patients with whooping cough.

Scand. J. Immun. 2000; 51 (5) : 530-532.

deMelker HE, JFP Schellekens, SE Neppelenbroek, FR Mooi, HC R�mke, MAE Conyn-van-Spaendock.
Re-emergence of pertussis in the highly vaccinated population of The Netherlands: observations on surveillance data.

Emerging Infectious Diseases 2000;6:348-357.

Pamela Cassiday, Gary Sanden, Kees Heuvelman, Frits Mooi, Kristine Bisgard, and Tanja Popovic.
Polymorphism in Bordetella pertussis pertactin and pertussis toxin virulence factors in the United States, 1935-1999.

J. Infect Dis 2000;182:1402-1408.

Mooi F, Hallander H, Wirsing von Koenig CH, Guiso N:
Epidemiological typing of Bordetella pertussis isolates: recommendations for a standard methodology.

Eur.J.Clin.Micro.&Infect.Dis.19:174-181, 2000

Koesters K, Riffelmann M, Dohrn B, Wirsing von Koenig CH:
Comparison of five commercial enzyme-linked immunosorbent assays for detection of antibodies to Bordetella pertussis.

Clin.Lab.Diagn.Immunol.7:422-426 2000

2001 _top

M�kinen J, Viljanen MK, Mertsola J, Arvilommi H, He Q.
Rapid identification of Bordetella pertussis pertactin gene variants using LightCycler real-time polymerase chain reaction combined with melting curve analysis and gel electorphoresis.

Emerg Infect Dis 7:952-958, 2001.

GUISO N., C. BOURSAUX-EUDE, C. WEBER, S.Z. HAUSMAN, H. SATO., M. IWAKI, K. KAMACHI & D.L. BURNS.
Analysis of Bordetella pertussis Isolates Collected in Japan Before and After Introduction of Acellular Pertussis Vaccines.

Vaccine (2001), 19, 3248-3252

GUISO N., C.H. WIRSING VON KONIG, C. BECKER & H. HALLANDER.
Fimbrial typing of Bordetella isolates: agglutination with polyclonal and monoclonal sera. Letters to the editor, no available abstract

J. Clin. Microbiol. (2001), 39, n� 4 : 1684-1685

GUERMONPREZ P., KHELEF N., BLOUIN E., RIEU P., RICCIARDI-CASTAGNOLI P., GUISO N., LADANT D., LECLERC C.
The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the M 2 integrin (CD11b/CD18).

J. Exp. Med. (2001), 193, n� 9 : 1035 -1044

KHELEF N., GOUNON P., GUISO N.
Internalization of Bordetella pertussis adenylate cyclase-hemolysin into endoxytic organelles is important for cytotoxicity.

Cell. Microbiol. (2001), 3, n� 11 : 721-730

WEBER C., BOURSAUX-EUDE C., CORALIE G., CARO V. & GUISO N.
Polymorphism of Bordetella pertussis isolates circulating the last ten years in France, where a single effective whole-cell vaccine has been used for more than thirty years.

J. Clin. Microbiol.(2001), 39, n�12 : 4396-4403

Bernard M. van den Berg, Silke David, Henry Beekhuizen, Frits R. Mooi, and Ralph van Furth.
Protection and humoral immune response against Bordetella pertussis infection in mice immunized with acellular pertussis vaccines and a whole-cell pertussis vaccine.

Vaccine 2001;19:1018-1028.

Hellwig-SMM; van-Oirschot-HFLM; Hazenbos-WLW; van-Spriel-AB; Mooi-FR; van-de-Winkel-JGJ.
Targeting to Fc gamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis.

J. Infect. Dis. 2001; 183 (6) : 871-879.

Mooi FR, Inge van Loo, and Audrey King.
Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence?

Emerg Infect Dis 2001;7(3 suppl): 526-528.

Hellwig S.M.M., A.B. van Spriel, J.F.P. Schellekens, F.R. Mooi and J.G.J. van de Winkel.
Immunoglobulin A-mediated protection against Bordetella pertussis infection.

Infect. Immun. 2001;69:4846-4850.

King, A., G. Berbers, P. Hoogerhout, H. van Oirschot, K. Knipping and F.R. Mooi.
Role of the polymorphic region 1 of the Bordetella pertussis protein pertactin in immunity

Microbiology, 2001; 147: 2885-2895.

Koesters K, Riffelmann M,Wirsing von Koenig CH:
Real-time LightCycler PCR for detection and discrimination of Bordetella pertussis and Bordetella parapertussis.

J.Med.Microbiology, 50:436-440 (2001)

Campins-Marti M, Cheng HK, Forsyth K, Guiso N, Halperin S, Huang LM, Mertsola J, Oselka G, Ward J, Wirsing von Konig CH, Zepp F:
Recommendations are needed for adolescent and adult pertussis immunisation: rationale and strategies for consideration.

Vaccine 2001; 20: 641-646

Saemann-Ischenko G, Tillmanns B, Koesters K, Riffelmann M, Wirsing von Koenig CH:
Stability of antibodies to Bordetella antigens in German adults.

Europ.J.Clin.Micro.Inf.Dis.20:850-853 (2001)

2002 _top

M�kinen J, Mertsola J, Viljanen MK, Arvilommi H, He Q.
Rapid typing of Bordetella pertussis pertussis toxin gene variants using LightCycler real-time PCR and fluorescence resonance energy transfer hybridization probe melting curve analysis.

J Clin Microbiol 40:2213-2216, 2002.

Wang J, Yang J, Li J, Mertsola J, Arvilommi H, Yuan L, Shen X, He Q.
Infantile pertussis rediscovered in China.

Emerg Infect Dis 8;859-861, 2002.

NJAMKEPO E., RIMLINGER F., THIBERGE S., ARMINJON F. & GUISO N.
Thirty-five years'experience with the whole-cell pertussis vaccine in France : continuing high quality, immunogenicity, efficacy, effectiveness.

Vaccine (2002), 20, 1290-1294

GILBERG S., NJAMKEPO E., PARENT DU CHATELET I., PARTOUCHE H., GUEIRARD P., GHFASAROSSIAN C., SCHLUMBERGER M., GUISO N.
Prevalence of pertussis infection in adults with persistent cough in a French area with a very high whole-cell vaccine coverage.

J. Infect. Dis. (2002), 186 : 415-418

SISTI F., FERNANDEZ J., RODRIGUEZ M.E., LAGARES A., GUISO N., HOZBOR D.F.
In vitro and in vivo characterization of a Bordetella bronchiseptica mutant strain with a deep rough lipopolysaccharide structure.

Infect. Immun. (2002), 70, n�4:1791-1798

WIRSING VON KONIG C.H., HALPERIN S., RIFFELMANN M., GUISO N.
Pertussis of adults and infants.

Lancet Infect. Dis. (2002), 2:744-750

Van Loo, IHM, CJ Heuvelman, AJ King and FR Mooi.
Multi-Locus Sequence Typing of Bordetella pertussis based on Surface Proteins genes.

J. Clin Microbiol. 2002;40:1994-2001

van Loo, I.H.M. and F.R. Mooi.
Changes in the Dutch Bordetella pertussis population in the first 20 years after the introduction of whole cell vaccines.

Microbiology, 2002; 148: 2011-2018.

Riffelmann M, Saemann-Ischenko G, Koesters K, Schmitt HJ, Wirsing von Koenig CH:
Antibodies to Bordetella antigens in pediatric health care workers

Ped.Inf.Dis.J.21: 381-83 (2002)

Juretzko P, Herrmann M, von Kries R, Wirsing von K�nig CH, Weil J, Giani G:
Effectivenes of accelular pertussis vaccines assessed by an active hospital based surveillance system in Germany

Clin.Inf.Dis.35: 167-67 (2002)

2003 _top

HOT D., ANTOINE R., RENAULD-MONGENIE G., CARO V., HENNUY B., LEVILLAIN E., HUOT L., WITTMANN G., PONCET D., JACOB-DUBUISSON F., GUYARD C., RIMLINGER F., AUJAME L., GODFROID E., GUISO N., QUENTIN-MILLET M-J., LEMOINE Y., LOCHT C.
Differential modulation of Bordetella pertussis virulence genes as evidenced by DNA microarray analysis.

Mol. Gen. Genet. (2003), 269:475-486

GUEIRARD P., AVE P., BALAZUC A-M., THIBERGE S., HUERRE M., MILON G. GUISO N.
Bordetella bronchiseptica in mice : not only these bacteria persist in the nasal cavity but they trigger an early delivery of dendritic cells in the lymph nodes draining the lower as well as the upper respiratory tract.

Infect. Immun. (2003), 71, n�7:4137-4143

KOUROVA N., CARO V., WEBER C., THIBERGE S., CHUPRININA R., TSENEVA G. and GUISO N.
Comparison of the Bordetella pertussis and Bordetella parapertussis isolates circulating in Saint Petersburg in 1998-2000 with the Russian vaccine strains.

J. Clin. Microbiol. (2003) 41, n�8:3706-3711.

M�KINEN J., MERTSOLA J., SOINI H., ARVILOMMI H., VILJANEN M.K., GUISO N., QIUSHUI H.
PFGE and pertactin gene sequencing suggest limited genetic variability within the Finnish Bordetella parapertussis population

. J. Med. Microbiol. (2003) 52 : 1059-1063

He, Qiushui, J. M�kinen, G. Berbers, F.R. Mooi, M.K. Viljanen, H. Arvilommi, and J. Mertsola.
The Bordetella pertussis protein pertactin induces type-specific antibodies: one possible explanation for the emergence of antigenic variants?

J. Infect. Dis. 2003; 187:1200-1205.

Hellwig S.M.M., M.E. Rodriguez, G.A.M. Berbers, J.G.J. van de Winkel, and F.R. Mooi.
Crucial Role of Antibodies to Pertactin in Bordetella pertussis Immunity.

J Infect Dis 188;2003:738-742.

Vandebriel R.J., S.M.M. Hellwig, J.P. Vermeulen, J.H.G. Hoekman, J.A.M.A. Dormans, P.J.M. Roholl and F.R. Mooi.
Association of Bordetella pertussis with host immune cells in the mouse lung.

Micro. Pathog. 2003; 35: 19-29.

De Greeff SC, JFP Schellekens, FR Mooi and HE de Melker.
Pertussis in The Netherlands,

2001-2003. RIVM Report 1285071010/2003.

2004 _top

Edelman K, He Q, M�kinen J, Haanpera M, Tran Minh MM, Schuerman L, Wolter J, Mertsola J.
Pertussis-specific cell-mediated and humoral immunity in adolescents 3 years after booster immunization with acellular pertussis vaccine.

Clin Infect Dis 2004 In press.

Poynten M, McIntyre PB, Mooi FR, Heuvelman KH, Gilbert GL.
Temporal trends in circulating Bordetella pertussis strains in Australia.

Epidemiol Infect. 2004 Apr;132(2):185-93.

Muyldermans, G., D. Pierard, N. Hoebrekx, R. Advani, S. Van Amersfoorth, I. De Schutter, O. Soetens, L. Eeckhout, A. Malfroot, and S. Lauwers..
Simple Algorithm for Identification of Bordetella pertussis Pertactin Gene Variants.

J Clin Microbiol 42:1614-9.

Advani, A., D. Donnelly, and H. Hallander
Reference System for Characterization of Bordetella pertussis Pulsed-Field Gel Electrophoresis Profiles..

J Clin Microbiol 42:2890-7.

DALET K., WEBER C., GUILLEMOT L., NJAMKEPO E., GUISO N.
Characterization of adenylate cyclase hemolysin gene duplication in a Bordetella pertussis isolate.

Infect Immun. (2004) 72, n�8: 4874-4877

BASSINET L., FITTING C., HOUSSET B., CAVAILLON JM., GUISO N.
Bordetella pertussis adenylate cyclase-hemolysin induces IL-6 secretion by human tracheal epithelial cells.

Infect. Immun. (2004) 72, n�9: